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The three international standards of ginkgo biloba extract
Mar 30, 2018

Ginkgo Biloba Extract

 

Ginkgo Biloba Extract is obtained from ginko biloba leaves.The main active ingredients of Ginko biloba are flavonol glycoside and terpene lactones.It has various health care functions and it is widely used in food and coametics.

 

Ginkgo Biloba extract.jpg

 

1.First Standard :

                    EP

European Pharmacopoeia 8.0

 

Charactristic

Bright yellow-brown,powder or friable mass

Identification

Thin-layer chromatography

Peak Area Ratio

-

Water/Loss on drying

-

Residue on Ignition

-

Heavy Metals

-

Ginkgolic Acids

≤5mg/kg

Flavonoids

expressed as   flavone glycosides

22%-27%

Terpene Lactones

Bilobalide 2.6%-3.2%

Ginkgolides A+B+C 2.8%-3.4%

Pesticide Residues

Comforms*

Sovlent Residues

Comforms*

Microbiology

-

ginkgo biloba leaf/Ginkgolides A+B+C.jpg

 

2.Second Standard:

              USP

 U.S.Pharmacopeia 36

 

Charactristic

-

Identification

1.Thin-layer chromatography

2.Kaempferol/Quercetin≥0.7,

     Isorhamnetin/Quercetin≥0.1

Peak Area Ratio

-

Water/Loss on drying

≤5.0%

Residue on Ignition

-

Heavy Metals

≤20mg/kg

Ginkgolic Acids

≤5mg/kg

Flavonoids

             expressed as   flavone glycosides

22%-27%

Terpene Lactones

Terpene lactones 5.4%-12%

Bilobalide 2.6%-5.8%

Ginkgolides A+B+C 2.8%-6.2%

Pesticide Residues

Comforms*

Sovlent Residues

Comforms*

Microbiology

Total aerobic bacterial count: ≤104cfu/g

Molds and yeasts: ≤103cfu/g

Salmonella species:negative

Escherichaia coli:negative

Ginkgo Bilobalode.jpg

 

3.Third Standard:

                  CP

Chinese Pharmacopoeia 2015

 

Charactristic

Light yellow brown to brown powder,

Slightly bitter taste

Identification

1.Thin-layer chromatography

2.Terpene lactones

Peak Area Ratio

Quercetin/Kaempferol =0.8-1.2

Isorhamnetin/Quercetin≥0.15

Water/Loss on drying

≤5.0%

Residue on Ignition

≤0.8%

Heavy Metals

≤20mg/kg

Ginkgolic Acids

≤10mg/kg

Flavonoids

             expressed as   flavone glycosides

≥24%

Terpene Lactones

Bilobalide+Ginkgolides A+B+C≥6%

Pesticide Residues

-

Sovlent Residues

-

Microbiology

Total aerobic bacterial count: ≤103cfu/g

Molds and yeasts: ≤102cfu/g

ginlgo biloba extract.jpg

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